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Dr. Raffaele Landolfi, Scientific Director of the Interactive Patient Simulation Experience (IPSE) Centre at the Catholic University and Policlinico Gemelli Foundation in Italy, discusses the advantages of virtual patients and simulation in assessing skills and professionalism, including managing errors, and protecting patients in medical education. The IPSE uses the CELL Methodology in simulation training that emphasizes experiential learning, and students interact in real-time with simulated patients who are actually located in a remote studio.